Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients
نویسندگان
چکیده
منابع مشابه
Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients
The aim of this study was to investigate the initiation and progression of autoimmune damage in the lesions of labial salivary glands (LSGs) from primary Sjögren's syndrome (SS) patients by examining the selective localization of T helper (Th) subsets such as Th1, Th2, Th17 regulatory T cells (T(regs)) and follicular T helper cells (Tfh). The expression of cytokines and transcription factors as...
متن کاملThe Histopathology of Labial Salivary Glands in Primary Sjögren's Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates
Recently, we revealed the importance of follicular helper T cells (T(FH)) in the pathogenesis of primary Sjögren's syndrome (pSS). In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on T(FH) and germinal center B cells. We selected tissue blocks obtained from ten...
متن کاملCommon T cell receptor clonotype in lacrimal glands and labial salivary glands from patients with Sjögren's syndrome.
Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration into lacrimal and salivary glands leading to symptomatic dry eyes and mouth. Immunohistological studies have clarified that the majority of infiltrating lymphocytes around the lacrimal glands and labial salivary glands are CD4 positive alphabeta T cells. To analyze the pathogenesis of T cells infiltrating...
متن کاملCharacterisation of follicular dendritic cells in labial salivary glands of patients with primary Sjögren syndrome: comparison with tonsillar lymphoid follicles.
OBJECTIVE To localise and characterise follicular dendritic cells (FDC) present in autoimmune lesions of primary Sjögren syndrome. METHODS Cryostat sections of labial salivary glands from 15 patients with primary Sjögren syndrome were examined by an indirect immunoperoxidase technique and monoclonal antibodies to a panel of dendritic cell markers. Tonsils from two controls were also examined ...
متن کاملUltrastructural localization of salivary mucins MUC5B and MUC7 in human labial glands.
As a result of their presence throughout the mouth in the submucosa or between muscle fibers, minor salivary glands secrete directly and continuously into the oral cavity, providing mucosal surfaces with highly glycosylated proteins that are active in bacterial aggregation and in oral tissue lubrication. In this study, we investigated the ultrastructural localization of the MUC5B and MUC7 mucin...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2012
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.2012.04606.x